Reproduction and genetic variation
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Lesson notes
Introduction to Reproduction and Genetic Variation
- **Genetic variation** refers to differences in DNA among individuals of the same species.
- Variation can be observed as **phenotypic variation** in traits like height or flower color.
- Two main types of reproduction: **asexual** (identical offspring) and **sexual** (variation).
- Sexual reproduction combines DNA from two parents, creating unique offspring.
Asexual Reproduction
- Offspring are **genetically identical** to the parent (clones).
- Occurs in bacteria (binary fission), yeast (budding), and some plants (runners).
- No fusion of gametes; no genetic variation except by mutation.
- Advantage: rapid population growth in stable environments.
Sexual Reproduction and Variation
- Involves **meiosis** to produce gametes (sperm and egg) with half the DNA.
- **Crossing over** during meiosis swaps DNA between homologous chromosomes, creating new allele combinations.
- **Independent assortment** of chromosomes during meiosis shuffles genes.
- **Random fertilization** combines any sperm with any egg, increasing variation.
Sources of Genetic Variation
- **Mutations** are changes in DNA sequence; they are the ultimate source of new alleles.
- Mutations can be **neutral**, **harmful**, or **beneficial**; most are neutral.
- **Genetic recombination** (crossing over and independent assortment) creates new combinations of existing alleles.
- **Gene flow** (movement of alleles between populations) introduces variation.
Types of Mutations
- **Small-scale** mutations: base-pair substitutions (point mutations) and indels (insertions/deletions).
- **Large-scale** mutations: chromosomal rearrangements (translocations, inversions) and copy number changes.
- **Polyploidy** (extra sets of chromosomes) is a type of chromosomal mutation common in plants.
- Mutations can occur in **somatic cells** (not inherited) or **germline cells** (passed to offspring).
Genetic Variation in Populations
- **Polymorphic genes** have more than one allele in a population.
- Variation is measured as the percentage of polymorphic loci or heterozygosity.
- **Natural selection**, **genetic drift**, and **gene flow** affect variation levels.
- **Balanced polymorphisms** (e.g., heterozygote advantage) maintain variation.
RNA Viruses and Variation
- RNA viruses have high mutation rates due to lack of proofreading.
- **Genetic recombination** in RNA viruses (e.g., influenza, HIV) generates new variants.
- Recombination can lead to outbreaks when new viral strains emerge.
Monohybrid cross showing 3:1 phenotype ratio from heterozygous parents.
DNA double helix with complementary base pairing (A-T, C-G).
Meiosis reduces chromosome number and generates variation through crossing over and independent assortment.
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Practice questions
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1.What is the main difference between asexual and sexual reproduction?
Easy- AAsexual reproduction produces genetically identical offspring; sexual reproduction produces genetically varied offspring.
- BAsexual reproduction produces genetically varied offspring; sexual reproduction produces genetically identical offspring.
- CBoth produce genetically identical offspring.
- DBoth produce genetically varied offspring.
2.Which process is the ultimate source of genetic variation?
Easy- AMutation
- BNatural selection
- CGenetic drift
- DGene flow
3.In a monohybrid cross between two heterozygous parents (Bb x Bb), what is the expected phenotypic ratio of dominant to recessive traits?
Medium- A3:1
- B1:2:1
- C1:1
- D9:3:3:1
4.During which stage of meiosis does crossing over occur, leading to genetic recombination?
Medium- AProphase I
- BMetaphase I
- CAnaphase II
- DTelophase II
5.A population of insects has two alleles for wing color: green (G) and brown (g). The frequency of the green allele is 0.7. Assuming Hardy-Weinberg equilibrium, what is the expected frequency of heterozygous individuals?
Hard- A0.42
- B0.49
- C0.09
- D0.21
6.Which of the following is an example of a large-scale structural variation in the genome?
Hard- AA base-pair substitution
- BA deletion of a 10 kb segment
- CA single nucleotide polymorphism
- DAn insertion of one base
7.A farmer uses cuttings from a single potato plant to grow many new plants. This is an example of which type of reproduction?
Easy- AAsexual reproduction
- BSexual reproduction
- CFertilization
- DMeiosis
8.Which diagram correctly shows the structure of DNA?
Medium- AA double helix with sugar-phosphate backbones and complementary base pairs
- BA single strand of nucleotides
- CA circular molecule with no base pairing
- DA triple helix with three backbones
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